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This family accommodates only one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was found to methylate, apart from histone, a variety of non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and parts of the TATA binding protein (TBP) advanced, TBP-related components TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Ok/R-S/T-K (goal lysine is bold), can be recognized by the H3K4 demethylase KDM1A/LSD1, which is capable of eradicating the methyl mark on most of these substrates 17 , ninety four Therefore KMT7/KDM1A has emerged as a classic model for dynamic lysine methylation of both histone and non-histone proteins. |
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